• br Results and discussion br Material and

  2018-11-12

  

  Results and discussion Material and methods Conclusions There are various applications for cell-based therapies in cartilage repair. For knee cartilage lesion treatment, autologous chondrocyte transplantation has become the principal cell-based approach. The first human autologous chondrocy

• br Materials and methods br Conflict of

  2018-11-12

  

  Materials and methods Conflict of interest statement Acknowledgements This work was supported by the National Natural Science Foundation of China (No. 81070798), Nature Science Foundation of Jiangsu Province (No. BK2009346), Funding Project to Science Facility in Institutions of Higher Lear

• In this study we have employed mouse NSCs

  2018-11-12

  

  In this study, we have employed mouse NSCs rather than human NSCs to explore the effects of PA. In view of this, further study would be desirable to ascertain if comparable effects of PA occur in human NSCs. In addition, elevated FFA level is intimately associated with oxidative stress and high leve

• The role of BDNF in the adult SVZ has been

  2018-11-12

  

  The role of BDNF in the adult SVZ has been analyzed by different groups with controversial results. Most studies with BDNF infusions or overexpression in the lateral ventricle demonstrated an increase in the number of newly born neurons in the olfactory bulb. However, Alvarez-Buylla\'s group showed

• It has been previously confirmed that SB selectively inhibit

  2018-11-12

  

  It has been previously confirmed that SB-505124 selectively inhibits TGF-β and activin signaling more efficiently than its analog SB-431542 (DaCosta Byfield et al., 2004), which has been shown to induce neural differentiation when used in combination with Noggin (Chambers et al., 2009). IWP-2, on th

• neuroscience peptides The second most stable reference

  2018-11-12

  

  The second most stable reference gene in the present study comparing OA- and healthy BMSCs is IPO8. The IPO8 gene product is a member of the importin-β family responsible for the nuclear import of proteins (Dean et al., 2001). Furthermore, it is involved in cytoplasmic miRNA-guided gene silencing an

• Lastly some targets of Foxd are also required

  2018-11-12

  

  Lastly, some targets of Foxd3 are also required to prevent aberrant apoptosis. Safb indirectly represses apoptotic genes in breast cancer po1 (Lee et al., 2007; Chan et al., 2007). Therefore, decreased Safb expression in Foxd3 mutant ESCs may lead to an increase in apoptosis. Finally, Pmaip1 (also

• For some genes the difference in transgene

  2018-11-12

  

  For some genes, the difference in transgene expression in BM/blood and other target organs can be both quantitative and qualitative. For example, the activities of introduced mct2 inhibitor α-glucosidase, which is deficient in a lysosomal glycogen storage disorder, Pompe disease, were different in b

• Recently efforts have been made to

  2018-11-12

  

  Recently, efforts have been made to identify differently expressed proteins during the osteogenic differentiation of hBMSCs (Alves et al., 2010; Foster et al., 2005; Kim et al., 2008, 2010; Ong and Mann, 2006; Zhang et al., 2007). These types of studies will not only increase our understanding of th

• Ras MAPK signaling is often deregulated

  2018-11-12

  

  Ras–MAPK signaling is often deregulated and is constitutively active in many types of cancers including pancreatic, colon, lung, melanoma and breast (Dunn et al., 2005). Activation of PI3K, Rac-1 and JNK was necessary for bFGF-induced fibroblast migration and blocking the activation of PI3K, Rac-1 o

• Technically these two antibodies have their limitations Both

  2018-11-12

  

  Technically, these two GDC0941 Supplier have their limitations. Both are better suited for immunofluorescent analysis in frozen tissue sections than in formalin-fixed paraffin-embedded tissues. In addition, anti-Lrig1-VU did not work for immunoprecipitation under our experimental conditions. FACS a

• br Materials and methods br Results br Discussion

  2018-11-12

  

  Materials and methods Results Discussion The roles of endogenous stem/progenitor buy Tubacin in adult pancreatic tissue homeostasis, acute/chronic injury response and tumor initiation remain uncertain. However, it is now clear that a subset of pancreatic duct cells are capable of initiating

• Naumann et al reported that the

  2018-11-09

  

  Naumann et al. (2010) reported that the absolute number of BrdU+ cells at 4 weeks after the last BrdU injection was similar between hAPP-I5 and control mice, which is inconsistent with our results. One possibility for this discrepancy might be the age of mice used in the studies. Six-week-old mice w

• We revealed the PGE enhanced transduction of human HSPCs

  2018-11-09

  

  We revealed the PGE2-enhanced transduction of human HSPCs by VSV-G-pseudotyped LV, possibly by acting on the endocytosis-dependent entry pathway. Applying PGE2 makes shorter ex vivo manipulation protocols that feature a single transduction cycle clinically viable, mitigating the negative effect of p

• Finally we demonstrate here that PML promotes

  2018-11-09

  

  Finally, we demonstrate here that PML promotes iPSC generation by facilitating the early activation steps. Our proposed model for its contribution to reprogramming is that PML activates mesenchymal marker activation (EMT), which in turn enhances epithelial (MET) and pluripotent gene activation, resu

15647 records 1023/1044 page Previous Next First page 上5页 10211022102310241025 下5页 Last page