• In this study we employed APEL based differentiation to

  2018-11-08

  

  In this study, we employed APEL-based differentiation to assess the contribution of WNT signaling to hematopoietic development from human embryonic stem cells. Although mesoderm formation was dependent upon WNT signals, WNT3A alone was an inefficient inducer of mesoderm. However, WNT3A synergized st

• The mechanisms that regulate the central properties

  2018-11-08

  

  The mechanisms that regulate the central properties of HSCs are not fully understood. Using the vast resource of ImmGen, we sought to identify genes with enriched HZ-1157 in HSCs, reasoning that such genes might represent key regulators of stem cell fate and function. In support of this, we readily

• GLPG0634 The aforementioned experiments demonstrated the ess

  2018-11-08

  

  The aforementioned experiments demonstrated the essential roles of Dbr/Hh signaling in midgut homeostasis. Next, we examined the source(s) of Hh involved in this process. We determined hh expression by using an hh-lacZ enhancer and Hh antibody. A high level of Hh expression was found in the anterior

• Mechanical signals play a crucial regulatory role in cardiac

  2018-11-08

  

  Mechanical signals play a crucial regulatory role in cardiac growth, development, and maintenance (Happe and Engler, 2016). Here, we developed a bioreactor system that exposes ESC-derived tizanidine hcl to defined pulsatile flow and cyclic strain, thereby mimicking in vivo physical signals that are

• Many studies Lee et al Fischer et

  2018-11-08

  

  Many studies (Lee et al., 2009; Fischer et al., 2009) have reported that intravenously injected BMSCs are initially trapped in the lung. However, it has also been shown that pulmonary trapping of infused apexbio dilution may be a transient phenomenon. Intravenously injected BMSCs or peripheral blood

• br Materials and methods br Results br Discussion We

  2018-11-08

  

  Materials and methods Results Discussion We have demonstrated the efficient generation of high numbers of bfCNs from hPSCs via an expandable basal forebrain NSC intermediate. This is of particular interest as bfCNs are one of the primary populations affected in AD, and our protocol provides

• br Introduction There are million

  2018-11-08

  

  Introduction There are 382million people with diabetes worldwide. All patients with Type I and approximately 25% of patients with Type II diabetes require exogenous insulin to survive (Koro et al., 2004). Unfortunately, insulin injections cannot match the minute-to minute precision that islets pr

• To further examine the influence of microgravity mechanical

  2018-11-08

  

  To further examine the influence of microgravity mechanical unloading on differentiation of mesenchymal and hematopoietic lineages, we investigated genes associated with terminal differentiation of these lineages. We found a broad down-regulation of early to mid stage differentiation markers and dow

• During neonatal and post natal development oligodendrocytes

  2018-11-08

  

  During neonatal and post-natal development, oligodendrocytes are abundantly produced in three temporally distinct waves (Kessaris et al., 2006), and differentiated oligodendrocytes express specific markers according to the state of development (Zhang, 2001). In the initial stage of differentiation,

• Pediatric MDS is a very rare disease and

  2018-11-08

  

  Pediatric MDS is a very rare disease and publications on the role of stroma in the ontogeny and maintenance of pediatric MDS are limited to a case report on aberrant hematopoietic support by MSC derived from an MDS patient with trisomy 8 (Narendran et al., 2004), a study using stroma testes of of 7

• br Methods br Results br Discussion

  2018-11-08

  

  Methods Results Discussion Originally, human bone marrow-derived CD34+ adenosine receptor agonist were defined as hematopoietic stem/progenitor-rich cells, while endothelial progenitor cells (EPCs), which play an important role in post-natal angiogenesis/vasculogenesis in ischemic tissues,

• br Materials and methods br

  2018-11-08

  

  Materials and methods Verification and authentication Karyotyping was performed at the Center for Applied Human Molecular Genetics, Kennedy Center, Glostrup, Denmark. At least 10 metaphases were analyzed per sample with an approximate resolution of 550 to 600 bands per haploid genome. The resu

• Microarray based global hierarchical clustering clearly sepa

  2018-11-08

  

  Microarray-based global hierarchical clustering clearly separated all the directly isolated keratinocyte populations. In the first round of analysis () where we focused on known and well characterized populations the Plet population clearly separated from the rest of the populations, which is probab

• The karyotype of the BIOT LOAD

  2018-11-08

  

  The karyotype of the BIOT-4828-LOAD iPSC line was determined with Giemsa-banding, proving normal diploid 46, XX karyotype, without any detectable abnormalities (Fig. 1B). Expression of pluripotency markers was examined by immunocytochemistry staining, using pdgfr against human OCT3/4, E-CADHERIN, a

• br Conclusions The following are the supplementary

  2018-11-08

  

  Conclusions The following are the supplementary data relate to this article. Disclosure of potential conflicts of interest Acknowledgments We thank Fondazione Roma for continuous support. We also acknowledge Prof. Mara Riminucci, Prof. Luca Pierelli, Dr. C. Murdoch, Dr. Paola Iudicone and

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