• Among the GWAS loci with more frequent lead

  2018-11-07

  

  Among the GWAS loci with more frequent lead SNPs (estimated MAF>5%) and corresponding validation GWAS or exome sequencing association signals, we observed p=3.34×10 for an intergenic SNP (rs9529561) on chromosome 13q21.33 which was also supported by the PROGRESS data (uncorrected p=0.035 for the ass

• Pyrrolidinedithiocarbamate ammonium The authors identified o

  2018-11-07

  

  The authors identified 13 other genetic variants that are promising candidates. None of these additional genetic variants reached the pre-specified level of statistical significance and therefore do not meet the discovery threshold but remain as promising candidates requiring further work and valida

• br Discussion Interestingly that the

  2018-11-07

  

  Discussion Interestingly, that the left RS accumulate significantly more adipose tissue than the right RS for both genders. Moreover, we did not find association between kidney size and RS adipose tissue volume. To the best of our knowledge, this anatomical phenomenon previously has not been desc

• In the resting state the presence of neutrophils in

  2018-11-07

  

  In the resting state the presence of neutrophils in glomeruli would be minimal and thus VWF-cleaving activity by neutrophil proteases negligible. During infection and inflammation neutrophil influx will occur and proteases released into the glomerular capillary lumen will migrate towards the subendo

• br Funding Sources Lundbeck Foundation Center for Clinical I

  2018-11-07

  

  Funding Sources Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) (R25-A2701 and R155-2013-16337), Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Mental Health Services, Capital Region of Denmark, and Faculty of

• Daniel Coit MD None Michael A Postow MD Bristol

  2018-11-07

  

  Daniel Coit, MD: None. Michael A. Postow, MD: Bristol Myers Squibb (Consulting or Advisory Role, Travel, Research Funding), Amgen (Consulting or Advisory Role), Novartis (Consulting or Advisory Role). Charlotte Ariyan, MD PhD: None. Author Contributions Introduction Colorectal cancer (CRC)

• The estimates of cancer free survival

  2018-11-07

  

  The estimates of cancer-free survival for the groups with 10-min Digoxigenin-11-UTP levels below and above the median showed an increasing divergence over the 40-year follow-up (Fig. 2). Thus, it is unlikely that causal factors related to glucose disposal at baseline were temporary in nature. It is

• Even if the DP of the method

  2018-11-07

  

  Even if the DP of the method calculated from this study is >0.99 (DP=0.995, as compared to 0.992 in our previous study (Gits-Muselli et al., 2015)), the distance between P. jirovecii genotypes remains low using our MLP typing method, resulting in a limited number of genetic groups. This low genetic

• br Acknowledgements This research is supported by Health Can

  2018-11-07

  

  Acknowledgements This research is supported by Health Canada. Specifications table Value of the data Data, materials and methods Acknowledgments Specifications table Value of the data Data and experimental design Fibroblasts are the most abundant cell type in connective tissues,

• br Data experimental design materials and

  2018-11-07

  

  Data, experimental design, materials and methods Data, experimental design, materials and methods Acknowledgments This work was supported by the Molecular and Cell Biology Research Center (MCBRC), Mazandaran University of Medical Sciences, Iran (grant number 1658); and the Iran National Sci

• We have reported that retinoids both RAs and

  2018-11-07

  

  We have reported that retinoids, both RAs and retinoic serine protease inhibitors receptor (RAR)/retinoid X receptor (RXR) analogs, are capable of enhancing macrophage cholesterol efflux, and these events involve activation of the LXR pathway [1,2]. Specifically, retinoid mediated macrophage cholest

• br Data Xylogenesis a process of wood fiber formation

  2018-11-07

  

  Data Xylogenesis (a process of wood fiber formation) is often characterized by two distinct stages: “early” and “late”. The first stage involves undifferentiated precursor pteryxin that are characterized by their primary cell wall, whereas the later stage includes a succession of events includin

• Official government figures forecast cement demand of

  2018-11-07

  

  Official government figures forecast cement demand of 3.5Mt/year by 2019 [22]. The demand projection at the anticipated peak demand phase (2016–2020) will grow 18% per year. This is linked to an expected boom in construction activity that normally occurs in emerging economies [33]. During the peak d

• br Conclusions br Acknowledgements This

  2018-11-07

  

  Conclusions Acknowledgements This research was supported by Grant no. BMBF 01EV0711 (German Ministry of Education and Research) and by the IMAGEN Project (PL037286) of the European Commission\'s 6th Framework Program (LSHM-CT-2007-037286). We acknowledge support by the German Research Foundati

• Finally we expected that the cannabis only group

  2018-11-07

  

  Finally, we expected that the cannabis-only group would show increased reward responding in the NAcc compared to the tobacco-only and control groups. However, no differences emerged between the cannabis-only group and any of the other groups. Importantly, cannabis use is becoming increasingly normat

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