• Introduction GPR is a class A type of

  2021-11-29

  

  Introduction GPR119 is a class A type of G Protein coupled receptor, which is expressed primarily in pancreatic β-cells and the K and L Lithocholic Acid of the gastrointestinal tract [1], [2], [3]. Activation of GPR119 promotes secretion of incretins such as glucagon-like peptide-1 (GLP-1) in the

• Next to their indirect effect on ASBT expression

  2021-11-29

  

  Next to their indirect effect on ASBT expression, microbiota are also directly involved in BA homeostasis and FXR-FGF15/19 signaling. Different species of intestinal microbiota have the ability to biotransform BAs mainly by deconjugation and subsequent de-hydroxylation, the latter resulting in more

• In this study three potential Otx binding

  2021-11-29

  

  In this study, three potential Otx-2 ApoBrdU DNA Fragmentation Assay Kit were found in the promoter region of the sheep GnRH gene: −1786 bp to −1770 bp, −825 bp to −819 bp, and − 529 bp to −523 bp. Combined with the results of the double-luciferase assay, it could be inferred that the binding site

• Herein we report the discovery of AM AM

  2021-11-26

  

  Herein, we report the discovery of AM-3189 (). AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. As we reported previously, activity on the GPR40 receptor varies significantly with substitution at the β-carbon relative to

• We confirmed a decrease in extracellular glutamate

  2021-11-26

  

  We confirmed a decrease in extracellular glutamate uptake and the presence of efflux in an endothelial cell model of oxygen-glucose deprivation (OGD), which effectively simulates the inefficient energy supply after brain injury [15], and analysed the function of endothelial EAATs and explored the ro

• The eradication of agonist activity

  2021-11-26

  

  The eradication of agonist activity in compound was also confirmed in the ex vivo growth hormone (GH) release experiment conducted in isolated primary rat pituitary Deforolimus sale as shown in . Compound did not produce any noticeable GH secretion at up to 10μM concentration. It could also antag

• As we showed earlier a to min

  2021-11-26

  

  As we showed earlier [19], a 20- to 30-min incubation with 2mM t-BHP resulted in erythrocyte swelling, which was less in a Ca2+-containing medium. Given that this effect was abolished in the presence of the Gardos channel inhibitor CLT, as well as in media high in K+, we suggested the contribution f

• Debio-1347 To date types of glucose transport protein have

  2021-11-26

  

  To date, 14 types of glucose transport protein have been discovered, each having its own specific functions with different distributions [33]. Among these, GLUT4 is particularly important for maintaining glucose metabolism homeostasis and insulin sensitivity, since it is involved in glucose transpor

• The normal function of the FBPase enzyme is

  2021-11-26

  

  The normal function of the FBPase enzyme is to catalyze the hydrolysis of F1,6BP to F6P. This activity is induced by diabetes and starvation and is increased in diabetic rats. The level of FBPase can be normalized by insulin, however, similar information is not available from diabetic patients. FBPa

• To evaluate the role of increased FPPS

  2021-11-26

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on Angiotensin I (human, mouse, rat) progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-

• Aberrant expression of HKII may be a required feature

  2021-11-26

  

  Aberrant expression of HKII may be a required feature for cancer development and progression. Overexpression of HKII has been reported in tumor tissues of cancer patients with liver [9], ovary [8], [24] and larynx [25]. The clinical significance of HKII in cancer was noted as overexpression of HKII

• Therefore we believe that HIF mediated effects on

  2021-11-26

  

  Therefore, we believe that HIF-mediated effects on CSC markers, apoptosis are mediated through HO-1. Our plan is to look for more mechanistic studies to understand the role of HO-1 degradation products (CO, Fe, and bilirubin) in cellular apoptosis, stemness under hypoxia. The model of role of HO-1 i

• We have previously reported on the effects of

  2021-11-26

  

  We have previously reported on the effects of replacing the isoquinoline P2∗ moiety with a naphthalene ring and modifying the connectivity for this element to the P2 proline ring, as demonstrated by compounds – (). Therein, it was hypothesized that the reduced potency observed with – when compared t

• The fact that GSK recognition of its substrate

  2021-11-26

  

  The fact that GSK-3 recognition of its substrate involves pre-phosphorylation supports the rational for using synthetic phosphorylated peptides as substrate competitive inhibitors [57]. Phosphorylated peptides derived from the N-terminal pseudosubstrate sequence of GSK-3β were very weak inhibitors o

• The stress of accelerated lactate production in cancer cells

  2021-11-26

  

  The stress of accelerated lactate production in cancer Senexin B is moderated by the overexpression of lactate transporters – symporters for lactate anions and protons called monocarboxylate transporters (MCTs) – that are capable of bidirectional transport depending on the environmental and/or cellu

15647 records 524/1044 page Previous Next First page 上5页 521522523524525 下5页 Last page