• br STAR Methods br Author Contributions br Acknowledgments T

  2020-07-31

  

  STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer

• The data presented in this manuscript along with studies

  2020-07-31

  

  The data presented in this manuscript along with studies by Lippested et al. using RvD1 (Lippestad et al., 2017) and Hodges et al. (2017) using LXA4, support the hypothesis that these SPMs play a dual role in the conjunctival goblet cells. The first role is to maintain homeostasis in normal, non-inf

• Acknowledgments The authors thank Pierre Alain Bayle

  2020-07-31

  

  Acknowledgments The authors thank Pierre-Alain Bayle for his contribution in the recording of NMR data and Colette Lebrun for ESI-MS spectrum. This research was supported by the Labex ARCANE (Grant ANR-11-LABX-0003-01). Introduction The activation of oncogenes during tumorigenesis generates DNA

• br Experimental br Results and discussions br Conclusion br

  2020-07-31

  

  Experimental Results and discussions Conclusion Introduction The joining of DNA fragments using DBU is an essential process in gene cloning. One of the important parameters for performing DNA ligation efficiently is the temperature [1]. In the case of DNA strands with cohesive ends, lig

• The proof of concept chemogenomic profiling experiments

  2020-07-31

  

  The proof of concept chemogenomic profiling experiments in P. falciparum (Fig. 3A) showed that the primary drug target can be revealed as a significant EC50 ratio. All antifolates were identified as DHFR-TS targeting drugs, despite the wide variation in antimalarial potency from the extremely potent

• E substrate interactions may be constitutive and in such

  2020-07-30

  

  E3-substrate interactions may be constitutive, and, in such cases, regulation can occur at the level of E3 transcription or degradation. The complexity of such trans-regulation is illustrated by the interplay of SCF and APC/C E3s during the cell cycle where, for example, APC/CCdh1 targets the F-box

• br Author contributions br Acknowledgements This work was su

  2020-07-30

  

  Author contributions Acknowledgements This work was supported by the State Fund for Fundamental Researches of Ukraine (grants F75-2018, F73-2018, F83-2018), Ukraine, grant No. 2.1.10.32-15 from National Academy of Sciences of Ukraine, Ukraine, Belarusian Republican Foundation for Fundamental R

• In a recent study Tomkins et

  2020-07-30

  

  In a recent study, Tomkins et al. [7] analyzed the protein-protein interaction network of ROCO proteins. Based on a database analysis, and only taking into account interactions reported in at least two peer-reviewed papers and/or confirmed by two different methods, 113 interactors were revealed for

• The following are the supplementary

  2020-07-30

  

  The following are the supplementary materials related to this article Funding This work was supported by grants from the University of Cape Town, the Carnegie Corporation of New York, CANSA, and the Medical Research Council of South Africa. Introduction The nuclear pore complex (NPC) is a gi

• We had previously observed a decrease in unspliced intron

  2020-07-30

  

  We had previously observed a decrease in unspliced, intron-containing HIV mRNA in infected murine cells (Coskun et al., 2007, Coskun et al., 2006, Elinav et al., 2012). The presence of human chromosome 2 in murine cells largely reversed this defect and significantly enhanced infectious virus product

• ARRY-380 Acknowledgements br Introduction Addiction is

  2020-07-30

  

  Acknowledgements Introduction Addiction is a life-long condition in which individuals show an intense drug craving and a high risk of relapse even after years of drug abstinence [1], [2]. A major goal of successful treatment of addiction is being able to prevent craving, seeking and relapse [3],

• br Results and discussion br Conclusions

  2020-07-30

  

  Results and discussion Conclusions The need for small-molecule probes and inhibitors of P4H is evident from the lack of structural information about this Cy5.5 NHS ester essential enzyme as well as the list of fibrotic diseases associated with collagen overproduction. The newly discovered rol

• In this work we directly

  2020-07-29

  

  In this work, we directly compared the effects on transcription by E. coli RNAP of several types of lesions commonly found in the genomic DNA: thymine dimer (CPD, cyclobutane pyrimidine dimer); 1,N6-ethenoadenine (εA); abasic site (AP); 8-oxoguanine (8oxoG), and thymine glycol (TG). We for the first

• br DGK modulates signalling events

  2020-07-29

  

  DGKε modulates signalling events through its specificity DAG kinases may also be responsible for enriching phosphatidylinositols with specific lipid components. Phosphatidylinositols are enriched at the sn−2 position with unsaturated fatty acids, usually arachidonate [37]. While it may seem that

• In all available crystal structures

  2020-07-29

  

  In all available crystal structures of TS-DHFR, a non-active site pocket which may accommodate small molecules is formed just above the crossover helix and adjacent to the DHFR domain of the bifunctional protein (B). Residues from both the crossover helix and Helix B of the DHFR catalytic domain for

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