• Apart from the CK isoforms and which are negatively regulate

  2020-07-28

  

  Apart from the CK1 isoforms γ3, δ, and ε, which are negatively regulated by autophosphorylation , , , CK1 isoforms are thought to be constitutively active and their regulation is thought to be at least partly mediated by localisation and/or complex formation (reviewed in ), which can be controlled b

• Hedgehog Hh signaling controls tissue

  2020-07-27

  

  Hedgehog (Hh) signaling controls tissue morphogenesis during embryogenesis [7]. It is activated when Hh ligands bind to patched (Ptc) receptors, subsequently releasing the Ptc-mediated repression of smoothened (Smo), and resulting in the activation of Gli transcription factors. Hh signaling plays a

• Chemokine receptor expression in MZL

  2020-07-27

  

  Chemokine receptor expression in MZL subtypes is shown in Table 1. CXCR3 is strongly expressed on the surface of the majority of MZLs and was identified via IHC in 14/14 (100%) patients with splenic MZL, 15/16 (94%) patients with extranodal MZL [4] and 5/5 (100%) cases of epidermotropic MZL [176].

• Atovaquone is a synthetic hydroxy naphthoquinone

  2020-07-27

  

  Atovaquone (2) is a synthetic hydroxy-naphthoquinone, structurally related to lapachol, which is very active against P. falciparum in both erythrocytic and liver stages of the protozoa life thymidylate synthase inhibitor and was introduced in malaria therapeutics in 2000. However, resistance was obs

• Substituents at the C position An oxygen

  2020-07-27

  

  Substituents at the C11 position — An oxygen-containing substituent at the C11 position also affects the catalytic activity of Δ1-KSTDs. The Δ1-KSTDs from the Gram-positive bacteria R. equi [29], N. simplex ATCC 6946 and IFO 12069 [48,49,52], and R. rhodochrous IFO 3338 [27] were able to 1(2)-dehydr

• GI 254023X DDRs a novel subfamily of receptor tyrosine kinas

  2020-07-27

  

  DDRs, a novel subfamily of receptor tyrosine kinases, were discovered during the search for tyrosine kinase proteins expressed in human malignancies 5, 6. DDRs can modulate cell responses such as adhesion, migration, differentiation, survival and proliferation, in response to the changes in the amou

• Altogether we have shown the presence of fully

  2020-07-27

  

  Altogether we have shown the presence of fully methylated DAPK fragments in serum of ovarian cancer patients but also of women with uterine leiomyoma. This indicates the prerequisite for the analysis of not only healthy controls but also of women with other frequent non-cancer disease for the valida

• Single celled eukaryotic ciliate protozoa are common in terr

  2020-07-27

  

  Single-celled eukaryotic ciliate protozoa are common in terrestrial, freshwater, and marine environments (Germond and Nakajima, 2016). As they have a small size enough to consume bacteria and small phytoplankton, ciliates play an important role in the planktonic and benthic microecosystems as transm

• SB 204070 br Acknowledgements This work was supported by

  2020-07-27

  

  Acknowledgements This work was supported by the National Natural Science Foundation of China (40976065, 41576116). Introduction Arachidonic SB 204070 via cytochrome P-450 (CYP450) can elicit the formation of lipid mediators with vasoactive actions: the epoxyeicosatrienoic acids (EETs) mainly

• This study also found that CuE significantly inhibited

  2020-07-27

  

  This study also found that CuE significantly inhibited P-gp activity with no effect on its expression. Since CuE presented potent inhibition on both CYP3A and P-gp activities in vitro, it may increase the exposed quantity of co-administered drugs in the body and cause drug-induced toxicity. To clari

• br Disclosure of interest br Introduction Among fossil fuels

  2020-07-27

  

  Disclosure of interest Introduction Among fossil fuels, natural gas is the cleanest, in terms of CO2 emission, burn efficiency and amount of air pollutant [1]. Methane is the prevailing element of natural gas; therefore, it contains other volatile molecules and a variety of impurities. In fac

• In plants SUMOylation has been shown to modulate plant

  2020-07-26

  

  In plants, SUMOylation has been shown to modulate plant hormone signaling (Lois et al., 2003, Miura et al., 2009, Conti et al., 2014), root stem cell maintenance (Xu et al., 2013), and responses to abiotic and biotic stress (Lois, 2010). Many of the plant biological processes regulated by SUMOylatio

• DSBs can be repaired by two major

  2020-07-25

  

  DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012). c-NHEJ comprises two sub-pathways, a resection-independent process and a resection-dependent process, and can rejoin break ends with little or no sequen

• br Conclusions br Conflict of interest statement br Acknowle

  2020-07-25

  

  Conclusions Conflict of interest statement Acknowledgments This research was funded by São Paulo Research Foundation (FAPESP) (ProcessN. 2012/08621-1). Thanks to F.J.H. Blázquez and the staff of the Laboratório de Anatomia Microscópica e Imuno Histoquímica (LAMIH − FMVZ − USP) for the permi

• A number of studies have been

  2020-07-25

  

  A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key Caspase-1, human recombinant proteinase of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Bras

15647 records 786/1044 page Previous Next First page 上5页 786787788789790 下5页 Last page