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Initially the E uses ATP to activate the C terminal
2019-10-08
Initially, the E1 uses ATP to activate the C-terminal glycine residue of ubiquitin prior to ligation. In the first step of E1 activation, the E1 catalyzes the adenylation of ubiquitin and pyrophosphate (PPi) release. In the second step, the E1 releases adenosine monophosphate (AMP) and a thioester b
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br Experimental methods br Results and discussion br
2019-10-08
Experimental methods Results and discussion Conclusion Rational design of highly selective fluorescent probes to detect G-quadruplexes is of profound importance for basic research. On this basis, we designed and synthesized a series of N-alkylated styrylquinolinium dyes Ls-1, Ls-2 and Ls-3.
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br As DAPK is dependent on Ca CaM
2019-10-08
As DAPK1 is dependent on Ca2+/CaM for its activity, its role in induction of autophagy is Ca2+-dependent and will be described in Section 5.1. LRRK1 and 2 were however shown to regulate autophagy in numerous studies where the role of Ca2+ was not investigated, and these mechanisms will be describe
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The study reported here had the primary goal
2019-10-08
The study reported here had the primary goal to compare the methylation of HPV late genes with methylation of the DAPK promoter, and with histological or cytological diagnoses among high-risk patients that were referred to a colposcopy clinic based on abnormal cervical cytology. Based on the literat
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The present study found a significant negative
2019-10-08
The present study found a significant negative correlation between miR-152-3p and CDK8 expression in human HCC tissues. We also validated that CDK8 was a direct target of miR-152-3p, and overexpression of miR-152-3p inhibited proliferation and induced apoptosis in HCC m6A by suppressing CDK8 expres
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In addition to its HEAT
2019-10-08
In addition to its HEAT repeats, CRM1 also possesses a C-terminal extension (C-extension, residues 1032–1071), composed of a helix (C-helix) followed by a short stretch of residues (C-tail). In the absence of Ran, the C-extension adopts a conspicuous conformation that bridges across the ring-shaped
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br Methods br Results br Discussion
2019-10-08
Methods Results Discussion The lowest intra-CeA dose of R278995/CRA0450 that prevented the elevations in Doxofylline reward thresholds associated with nicotine withdrawal was 0.05μg/side (0.1μg total bilateral dose). The total bilateral dose in the present study is 100 times lower than the
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This study demonstrates that GUL affects multiple pathways p
2019-10-08
This study demonstrates that GUL-1 affects multiple pathways/processes. As GUL-1 is likely to function as an RNA-binding protein, it is conceivable that the mRNAs involved are bound to GUL-1 as part of the regulatory function of the protein. In fact, in S. cerevisiae Ssd1 was shown to bind multiple
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Several reasons may explain that other studies using PDE
2019-10-08
Several reasons may explain that other studies using PDE-5-Is yielded negative or contradictory results [30], [31], [32]. Lee [30] applied 50mg sildenafil to seven patients with liver cirrhosis. NO and cGMP in the hepatic rifampicin kinase significantly increased, hepatic and pulmonary resistance
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In the frontal cortex the present study found a relationship
2019-10-07
In the frontal cortex, the present study found a relationship between working memory performance and activated Erk2 expression for the E2-only group, where animals that tended to perform better on the WMC measure tended to have higher activated Erk2 expression. This suggests that there is a unique r
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br Introduction Ewing s sarcoma ES is
2019-10-07
Introduction Ewing’s sarcoma (ES) is a mesenchymal tumor characterized by small, round, blue cells, and is poorly differentiated and highly malignant [1]. While ES typically arises in bone and soft tissue, rare primary extraosseous manifestations of ES have been reported throughout the body [2].
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Other GPCRs notable for changes
2019-10-07
Other GPCRs notable for changes in expression on CLL cells include upregulation of the thromboxane A2 receptor TBXA2R mRNA [61] and up and downregulation of mRNA and protein from the neurotensin receptors NTSR2 and NTSR1, respectively [62]. The Eμ-TCL1 mouse model of CLL has been used to study mult
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HOIP s ability to build linear Ub
2019-10-07
HOIP\'s ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [4
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In a study carried out by Aunis et al
2019-10-07
In a study carried out by Aunis et al. the properties of soluble DBH and membrane bound were examined [23]. The membrane bound enzyme was shown in KH CB19 to the soluble form to have thermal denaturation at higher temperatures of 43.5–44°C. Similar discontinuities in the Arrhenius plots were obtain
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In a study carried out by Aunis et al
2019-10-07
In a study carried out by Aunis et al. the properties of soluble DBH and membrane bound were examined [23]. The membrane bound enzyme was shown in WWL 70 to the soluble form to have thermal denaturation at higher temperatures of 43.5–44°C. Similar discontinuities in the Arrhenius plots were obtaine
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