nicergoline br Experimental Procedures br Acknowledgments br

2018-10-20

Experimental Procedures Acknowledgments Introduction Master transcription regulators control the pluripotent gene expression in embryonic stem nicergoline (ESCs) (Avilion et al., 2003; Chambers et al., 2003; Mitsui et al., 2003; Nichols et al., 1998). X chromosome inactivation (XCI) is a cr

br Experimental Procedures br Acknowledgments br Introductio

2018-10-20

Experimental Procedures Acknowledgments Introduction Articular cartilage covers the ends of bones and provides shock RG7388 and lubrication to diarthrodial joints. Articular cartilage is a highly specialized tissue composed of chondrocytes and a specific extracellular matrix (ECM) that con

In order to clarify such method dependent

2018-10-20

In order to clarify such method-dependent reprogramming hallmarks, we applied standard assays to compare polycistronic cassettes (constructed in-house or obtained from public resources) in a drug-inducible piggyBac (PB) transposon reprogramming system. The induced expression of various polycistronic

br Materials and methods br Results br

2018-10-20

Materials and methods Results Discussion Several in vivo and in vitro studies indicate that OPCs have substantially different properties according to their chronological age. For example, human fetal OPCs from different gestational stages exhibit differences in the myelination profile (Cui

The majority of the characterized NETs bind

2018-10-20

The majority of the characterized NETs bind lamins and/or chromatin binding proteins (Harr et al., 2016; Kind et al., 2013; Wong et al., 2014). Chromatin proteins in pluripotent stem ache inhibitors display hyperdynamic plasticity (Chen and Dent, 2014; Meshorer et al., 2006). During differentiation

br Discussion Our study provides insights into the mechanism

2018-10-20

Discussion Our study provides insights into the mechanisms underlying the loss of regenerative potential and increasing fibrogenesis with age in DMD. We report that a proportion of specialized cells, which are critical for muscle regeneration, cannot maintain their identifying functions in aged d

Transplantation assays which measure the potential of cells

2018-10-20

Transplantation assays, which measure the potential of lrrk2 under investigation, traditionally were used as the gold standard for characterizing tissue stem cells. However, recent studies in epithelial tissues based on pulse-chase lineage-tracing approaches, which measure the activity of primary c

Here using several murine and human cellular

2018-10-20

Here using several murine and human cellular models, we present compelling evidence for ASYN expression during oligodendrocyte lineage cell development. Moreover, we identified both ASYN protein and transcripts in purified PDGFRA/CD140a+ oligodendrocyte progenitors and oligodendrocyte lineage SOX10+

Because Q SA and Q SC represent an

2018-10-20

Because Q3SA and Q3SC represent an isogenic pair of iPSC lines from the same individual but with contrasting ATM genotypes (ATM−/− versus ATM+/−, respectively), we examined gene expression differences using RNA sequencing (RNA-seq), evaluating matches at the transcript level. Relatively few mRNAs we

However PSCs have major safety concerns such as teratoma

2018-10-20

However, PSCs have major safety concerns, such as teratoma formation due to possible contamination of the residual undifferentiated PSCs (Lee et al., 2013a). Teratoma is a unique characteristic of PSCs owing to their pluripotency and ability to undergo unlimited proliferation (Gruen and Grabel, 2006

br Introduction Neural tube defects NTDs are

2018-10-20

Introduction Neural tube defects (NTDs) are still poorly understood, especially for human and non-human primates (NHPs) (Wallingford et al., 2013). In rhesus monkeys, at embryonic day 19–20 (E19–20), the neural tube (NT) contains multiple pseudostratified layers of neuroepithelial stem cells (NES

br Introduction Neural stem cells NSCs are

2018-10-20

Introduction Neural stem cells (NSCs) are a class of multipotent cells responsible for generating all types of neural cells in the nervous system and for maintaining the stem cell population by self-renewal (Gage, 2000). The transition of proliferative and multipotent NSCs to fully differentiated

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments The authors thank Chyuan-Sheng Lin from the Transgenic Mouse Facility at the Herbert Irving Comprehensive Cancer Center at Columbia University for development of the Zfyve27-CreERT2 mice; Theresa Swayne from the Confocal and Speci

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2018-07-29