• The ability of tumors to progress to more

  2019-06-26

  

  The ability of tumors to progress to more malignant phenotypes depends on tumor microenvironment. Blood capillaries, made up of endothelial cells, are usually static under physiological conditions but are induced to proliferate by direct exposure to angiogenic factors, for instance, vascular endothe

• br Introduction Atrial fibrillation AF is the most

  2019-06-26

  

  Introduction Atrial fibrillation (AF) is the most clinically prevalent tachyarrhythmia [1,2]. AF is a potential risk factor for stroke, and AF-associated strokes are often severe, resulting in disability or death [3–6]. Anticoagulant therapy with the vitamin K antagonist warfarin reduces the risk

• More recently Brugada et al used flecainide to

  2019-06-26

  

  More recently, Brugada et al. [131]. used flecainide to identify the full extent of low-voltage electrogram activity in the anterior RV and RVOT and targeted this region for RFA. In all 14 BrS patients, RFA eliminated abnormal bipolar electrograms, normalized ST-segment elevation on right precordial

• The IntellaTip Mifi catheter has been shown to delineate

  2019-06-26

  

  The IntellaTip Mifi catheter has been shown to delineate local electograms better in the isthmus than the conventional bipolar electrode during atrial flutter ablation. The signal amplitude in the mini-electrodes has been noted to be higher than that of the conventional bipolar catheter. This has en

• The indications for epicardial mapping are institutionally

  2019-06-25

  

  The indications for epicardial mapping are institutionally variable but typically performed after a failed endocardial approach or if the etiology of cardiomyopathy suggests a high likelihood of epicardial scar (Fig. 9). Studies of patients with NICM that underwent combined epicardial–endocardial ap

• br Introduction Sudden cardiac death

  2019-06-25

  

  Introduction Sudden cardiac death (SCD) in patients with low ventricular function remains a substantial problem despite improved medical therapies [1–3]. Many patients require antiarrhythmic drugs to prevent recurrent arrhythmias and reduce the number of shocks from implanted cardioverter-defibri

• Limitations of meta analyses are often based on

  2019-06-25

  

  Limitations of meta-analyses are often based on the strength of the data available. Only 26% of the eligible studies were judged to be at low risk of overall bias in this analysis. Other studies may have been at low risk for bias but failed to report information necessary for this determination. All

• By GBD region in the

  2019-06-25

  

  By GBD region, in the past two decades, the largest increases in incidence of ischaemic stroke were in eastern Europe, central and east Asia, north and sub-Saharan Africa, and the Middle East (figure 1), with the largest increase (22%) noted in the Democratic Republic of Congo. Notably, some of the

• In this issue of Mark Nicol and colleagues report the

  2019-06-25

  

  In this issue of , Mark Nicol and colleagues report the diagnostic accuracy of two commercially available rapid urine tests to identify active tuberculosis in children. Lipoarabinomannan is a unique component of the mycobacterial Nelfinavir that is excreted in the urine of some patients with tubercu

• El eje dram tico de En la prisi n se

  2019-06-25

  

  El eje dramático de En la prisión… se va desarrollando Rofecoxib what través de los relatos que el Profesor, un militante de la vanguardia política revolucionaria cubana, sueña que, a su vez sueña, que narra a un grupo de “negros” durante un agobiante verano habanero de los años noventa. Todo sucede

• In subgroup analysis of the types of hospice as classified

  2019-06-25

  

  In subgroup analysis of the types of hospice as classified by the administrative authorities (Table 3), there was a trend that the patients admitted to a public hospital had a higher rate of dying in a hospice than those admitted to a private hospital, especially in the military and veterans\' hospi

• br Conclusion br Conflict of interest This work was supporte

  2019-06-25

  

  Conclusion Conflict of interest This work was supported by Medtronic Japan. MN received honoraria from Medtronic Japan, St. Jude Medical Japan and Boston Scientific Japan. YE and TI received honoraria from Medtronic Japan. HS received honoraria from Japan Lifeline. YA, TT, and KK are employees

• Landiolol is an ultra short acting superselective titration

  2019-06-25

  

  Landiolol is an ultra-short-acting, β1-superselective, titration intravenous β-adrenergic blocker that is rapidly metabolized to inactive forms, and has relatively smaller negative inotropic effects on the cardiac output [11]. Landiolol is more effective for controlling rapid tnf alpha inhibitors r

• br Discussion Studies have reported that permanent PMI using

  2019-06-25

  

  3. Discussion Studies have reported that permanent PMI using the conventional pectoral approach is impossible or contraindicated in 1–6% of patients [1–5]. In such patients, PMI via the iliac vein is considered an effective alternative. The advantages of this approach are that the wound size and

• External parties ability and willingness to fund

  2019-06-25

  

  External parties\' ability and willingness to fund health interventions is also an important factor in how governments decide on their spending priorities. Historically, development partners have funded prevention and treatment for a key group of diseases. Furthermore, a diverse set of barriers prev

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