• In the current study we used only gene expression

  2018-10-20

  

  In the current study, we used only gene expression data for the analysis; however, phosphoproteomics data could also be used to assign weights to the signaling interactome for the inference of niche determinants. An important limitation of the method is that it considers only DERs as the sources of

• silybin The relationships of the proximal fetal lung progeni

  2018-10-20

  

  The relationships of the proximal fetal lung progenitor pool characterized in this study to other epithelial cell types remain to be investigated. In the proximal lung of adult animals, either club silybin expressing SCGB1A1 or basal cells expressing KRT5, ITGA6, and NGFR (and others) acts as multip

• br Results br Discussion Adrenergic

  2018-10-20

  

  Results Discussion α-Adrenergic receptors play a critical role in the regulation of cellular growth pathways, including hypertrophy and proliferation. G protein-coupled α1ARs are the predominant α-adrenergic subtype in the myocardium of most species (Brückner et al., 1985), and catecholamine r

• prolyl hydroxylase Here we set out to evaluate the roles of

  2018-10-20

  

  Here we set out to evaluate the roles of transcriptional regulators associated with EMT in iPSC reprogramming. We were intrigued by data from published reports that EMT factors (including SNAI1) increased during the early stages of reprogramming (Mikkelsen et al., 2008; Samavarchi-Tehrani et al., 20

• daunorubicin To address this need we have developed a functi

  2018-10-20

  

  To address this need, we have developed a functional imaging approach for CSC identification. The stem cell phenotype in embryonic stem daunorubicin (ESCs) is maintained by a central triad of master transcriptional regulators, OCT4, SOX2, and NANOG, which promote stemness by upregulating genes invo

• br Results br Discussion Abnormally elevated levels of BMP

  2018-10-20

  

  Results Discussion Abnormally elevated levels of BMP2 were specifically detected in luminal breast tumors but produced by tumor microenvironment and not by cancer anti fungal themselves as reported in leukemia (Gerber et al., 2013; Laperrousaz et al., 2013). Chronic exposure to BMP2 in the pre

• nicergoline br Experimental Procedures br Acknowledgments br

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Master transcription regulators control the pluripotent gene expression in embryonic stem nicergoline (ESCs) (Avilion et al., 2003; Chambers et al., 2003; Mitsui et al., 2003; Nichols et al., 1998). X chromosome inactivation (XCI) is a cr

• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Articular cartilage covers the ends of bones and provides shock RG7388 and lubrication to diarthrodial joints. Articular cartilage is a highly specialized tissue composed of chondrocytes and a specific extracellular matrix (ECM) that con

• In order to clarify such method dependent

  2018-10-20

  

  In order to clarify such method-dependent reprogramming hallmarks, we applied standard assays to compare polycistronic cassettes (constructed in-house or obtained from public resources) in a drug-inducible piggyBac (PB) transposon reprogramming system. The induced expression of various polycistronic

• br Materials and methods br Results br

  2018-10-20

  

  Materials and methods Results Discussion Several in vivo and in vitro studies indicate that OPCs have substantially different properties according to their chronological age. For example, human fetal OPCs from different gestational stages exhibit differences in the myelination profile (Cui

• The majority of the characterized NETs bind

  2018-10-20

  

  The majority of the characterized NETs bind lamins and/or chromatin binding proteins (Harr et al., 2016; Kind et al., 2013; Wong et al., 2014). Chromatin proteins in pluripotent stem ache inhibitors display hyperdynamic plasticity (Chen and Dent, 2014; Meshorer et al., 2006). During differentiation

• br Discussion Our study provides insights into the mechanism

  2018-10-20

  

  Discussion Our study provides insights into the mechanisms underlying the loss of regenerative potential and increasing fibrogenesis with age in DMD. We report that a proportion of specialized cells, which are critical for muscle regeneration, cannot maintain their identifying functions in aged d

• Transplantation assays which measure the potential of cells

  2018-10-20

  

  Transplantation assays, which measure the potential of lrrk2 under investigation, traditionally were used as the gold standard for characterizing tissue stem cells. However, recent studies in epithelial tissues based on pulse-chase lineage-tracing approaches, which measure the activity of primary c

• Here using several murine and human cellular

  2018-10-20

  

  Here using several murine and human cellular models, we present compelling evidence for ASYN expression during oligodendrocyte lineage cell development. Moreover, we identified both ASYN protein and transcripts in purified PDGFRA/CD140a+ oligodendrocyte progenitors and oligodendrocyte lineage SOX10+

• Because Q SA and Q SC represent an

  2018-10-20

  

  Because Q3SA and Q3SC represent an isogenic pair of iPSC lines from the same individual but with contrasting ATM genotypes (ATM−/− versus ATM+/−, respectively), we examined gene expression differences using RNA sequencing (RNA-seq), evaluating matches at the transcript level. Relatively few mRNAs we

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