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br Site of expression FASTK
2022-09-07
Site of expression FASTK is expressed in various parts of human body including heart, skeletal muscle, brain, placenta, lung, liver, kidney pancreas (Ota et al., 2004) and many other organs (Fig. 1). It has been reported that FASTK is highly expressed in pancreatic tumors, where it is involved in
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Apoptosis via Fas FasL system has been
2022-09-07
Apoptosis via Fas/FasL system has been evidenced to play a role in the pathogenesis of many diseases [26], [27], [28], [29], [30], [31], [32], [33], [34]. Along with these, Fas/FasL system has an important role in progressive renal disease and organ rejection in renal, cardiac and liver transplant
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The results of our analysis of Fas alleles
2022-09-07
The results of our analysis of Fas alleles, Fas 670 A>G, FasL alleles, and FasL IVS2nt 124 A>G for cases and controls are shown in Table 2. For Fas 670, we found statistically significant differences between the two groups regarding the AA Pyr3 (P=0.040) and GG/AG (P=0.040) as well as the A and G al
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The molecular target of N BPs is farnesyl
2022-09-07
The molecular target of N-BPs is farnesyl diphosphate synthase (FPPS), a crucial enzyme at the branch point of cholesterol and isoprenoid synthesis in the mevalonate pathway [5]. Because they bind calcium ions, N-BPs accumulate quickly in the skeleton and are internalised by osteoclasts, leading to
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Previous studies have shown that ox LDL induced
2022-09-07
Previous studies have shown that ox-LDL-induced hepatic sinus dysfunction is the result of multiple pathways, multi-factorial regulation, and in the present study, we reported for the first time that ox-LDL regulates the basement membrane protein VN through the integrin αvβ5 pathway under high gluco
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It is well known that TLR induced inflammation is
2022-09-07
It is well known that TLR4-induced inflammation is associated with behavioural alterations including fever, hypolocomotion, altered appetite, anxiety and anhedonia (Dantzer, 2006, Dantzer et al., 2008). The current data demonstrate that while PF3845 potently attenuates TLR4-induced cytokines in the
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br Results br Discussion In
2022-09-07
Results Discussion In this study, six new T30695 variants were synthesized with the acyclic R or S glycerol linker instead of poly ic unit at 4, 8 or 12 T residue. Based on our previous studies on TBA-GQ, this type of modification should provoke local changes in GQ conformations in the final
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br Funding The research for this
2022-09-07
Funding The research for this paper is conducted as part of a PhD thesis at Pasteur Institute of Iran and it was financially supported by Pasteur Institute of Iran and the Iranian Centre for Communicable Diseases. Conflict of interest Acknowledgments Introduction The viral enzyme integr
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Utilization of fascinating properties such as
2022-09-07
Utilization of fascinating properties, such as localized surface plasmon resonance (LSPR), high fluorescent quantum yield, biocompatible nature, chromogenic and electrocatalytic functionality of several nanomaterials for histamine sensing is also quite evident where the nanomaterials have served as
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The site of metastasis in breast cancer often contributes to
2022-09-07
The site of metastasis in breast cancer often contributes to the patient’s OS. Patients with bone metastasis from their breast cancer often have a notably increased survival over patients with visceral or tandospirone metastasis. In this analysis, ER+/HER2+ patients were noted to have a higher rate
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Xie et al b reported that the combination of diagnostic
2022-09-03
Xie et al. (2009b) reported that the combination of diagnostic ultrasound impulses and cyclic RGD-bearing MBs targeted for GP IIb/IIIa resulted in the successful recovery of epicardial and microvascular blood flow in swine models with acute thrombotic occlusion. It is well known that the stability o
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Several reports have shown that
2022-09-03
Several reports have shown that the ICD of CLRs is involved in the desensitization process of this superfamily. The analysis of our chimeric constructs between GlyRα1 and GLIC revealed differences in desensitization properties. In contrast, other ion channel properties such as channel block and ion
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br Conclusion In summary a series of novel GPR agonists
2022-09-03
Conclusion In summary, a series of novel GPR40 agonists bearing phenylpropiolic LY3023414 motif with favorable metabolic stability were prepared and evaluated for their activities as GPR40 agonists. Among them, compound 9 was identified as a structurally distinct GPR40 agonist possessing potent
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br Materials and methods br Results and discussion br Conclu
2022-09-03
Materials and methods Results and discussion Conclusion Altogether, our data provide an unexpected insight into Cx26 trafficking pathway and gap junction assembly in the cochlea. Since many of the disease-causing mutations in GJB2 impair the trafficking and delivery of Cx26 to the cell surf
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Because of its role in the cleavage
2022-09-03
Because of its role in the cleavage of Aβ and the fact that many genetic forms of AD are caused by mutations in the enzyme, GS has long been a target for drug development, though previous clinical trials of Semagacestat, a GS inhibitor, have failed due to an increase in skin cancer, and a decrease i
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