• Adenosine triphosphate ATP is thought to be a

  2022-08-12

  

  Adenosine triphosphate (ATP) is thought to be a crucial molecule in acute pain signaling in the DRG, as well as in the development and maintenance of chronic pain (Burnstock, 2009, Burnstock, 2013, Burnstock, 2014, Chizh and Illes, 2001). Extracellular ATP activates the ionotropic P2X receptors (Bur

• Patient characteristics are presented in Serum oestradiol le

  2022-08-12

  

  Patient characteristics are presented in . Serum oestradiol levels on the day of oocyte retrieval or warming were higher in group A (253.2 pg/ml) compared with group B (192.6 pg/ml), despite a significantly reduced number of days (mean 3.5 days) taking oestrogens without the addition of progesterone

• Among the compounds prepared at this stage the cyclopropylme

  2022-08-12

  

  Among the compounds prepared at this stage, the cyclopropylmethylenoxy analogue attracted our most attention since it demonstrated particularly good in vitro potency at GlyT1 (16nM), no activity at the GlyT2 isoform up to the highest concentration tested (30μM), good physical properties with modera

• Diabetes induced damage results in peripheral nerve patholog

  2022-08-12

  

  Diabetes-induced damage results in peripheral nerve pathology that chembridge correlates with clinical signs and symptoms. Nerve injury that results in structural changes can be measured through clinical neurological assessment, quantitative sensory testing, nerve conduction studies, and peripheral

• br The glycine transporter GlyT was originally

  2022-08-12

  

  The glycine transporter 1 (GlyT1) was originally identified as a member of the solute carrier family 6 of sodium- and chloride-dependent neurotransmitter transporters . GlyT1 is expressed in the central nervous system and in peripheral tissues; mainly in erythroid cells, from erythroblasts in the

• FPG had no consistent activity in reducing G T

  2022-08-12

  

  FPG-2 had no consistent activity in reducing G→T transversions. Gao and Murphy [2] earlier reported that FPG-2 had a limited amount of activity in vitro on depurinated, UV-treated, and methylene-blue-treated DNA (but not on 8-oxo-G-containing oligonucleotides). FPG-2 contains the N-terminal domain a

• Tail group SAR of the imidazole derived analogs

  2022-08-12

  

  Tail group SAR of the imidazole derived analogs is shown in . The previous SAR study from the discovery of AMG 837 revealed that a simple un-substituted meta-biphenyl tail group was less favorable in terms of potency. Efforts to introduce polarity to the tail group were not successful. When a methyl

• gpr120 agonist In this present study the availability

  2022-08-12

  

  In this present study, the availability of commercial GLUT and SGLT gpr120 agonist directed against different epitopes, enabled us to screen for members of the SGLT family and compare the expression patterns of GLUTs and SGLTs in the different regions of the rat lens. Based on these regional and sub

• For another the N terminal sequence of native glucagon

  2022-08-12

  

  For another, the N-terminal sequence of native glucagon is highly conserved, and positions 8, 9, 16 and 18 are noteworthy in maintaining glucagon activity [18], [20], [21]. It also achieves a degree of selectivity from its C-terminal residues, and a significant contribution is made by the C-terminal

• Although GLP has greater insulin

  2022-08-12

  

  Although GLP-1 has greater insulin-releasing effects at pharmacological concentrations [10], it is apparent that the higher circulating concentrations of GIP combined with more pronounced increase in secretion following feeding make GIP the major physiological incretin [7], [11]. The peptide exerts

• Ghrelin is mostly known for

  2022-08-12

  

  Ghrelin is mostly known for its orexigenic properties, whereas the role of DAG on feeding is controversial with studies claiming an orexigenic, anorexigenic or no effect (Inhoff et al, 2009, Toshinai et al, 2006). One of these studies was that of Toshinai and colleagues, who found a link between the

• br Central control of GI ghrelin secretion The CNS

  2022-08-12

  

  Central control of GI ghrelin secretion The CNS communicates with the GI tract through the vagus nerve originating in the DMV and sympathetic spinal afferents emanating from the thoracic spinal chord (Bray, 2000). The cells that secrete peripheral ghrelin are under direct control of these two pat

• br Materials and methods br Results br Discussion

  2022-08-12

  

  Materials and methods Results Discussion Several peripheral hormones that are involved in the central regulation of energy homeostasis, such as leptin, insulin, and amylin [34], [35], [36], [37], [38], cross the BBB by saturable and unsaturable mechanisms. Whether these transport processes

• br Materials and methods br Conflicts

  2022-08-12

  

  Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He

• br Acknowledgments br Introduction When human red blood cell

  2022-08-12

  

  Acknowledgments Introduction When human red blood cell (hRBC) membranes are depolarized, either as intact estrone suspended in depolarizing (low Cl−) Ringers or under voltage clamp conditions using excised inside-out patches, they respond by opening a nonselective voltage-dependent cation (NS

13329 records 222/889 page Previous Next First page 上5页 221222223224225 下5页 Last page