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In order to elucidate the
2021-09-13
In order to elucidate the mechanisms behind the observed changes in metabolic activity in the cardiomyoblasts we investigated changes in gene and protein expression subsequent to treatment with PSN632408 with or without concurrent exposure to palmitate. Activating GPR119 in basal and high palmitate
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Consistent with other studies on the
2021-09-13
Consistent with other studies on the metabolic effects of an OM3 enriched diet [26,104,105], irrespective of gender, the lowest glucose levels were seen in the Bob-Cat groups fed OM3 diet. Sexual dimorphism was observed in insulin levels. The highest average levels were in the HFD fed [Tg(CAT)±] mal
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In women with stage I II
2021-09-13
In women with stage I–II endometriosis [17], no difference in the implantation rate per embryo or in the clinical pregnancy rate per transfer was noted between GnRH-agonist and GnRH-antagonist protocol (18.2% vs. 15.4%, P=0.9 and 31.2% vs. 30%, P=1, respectively). It has been suggested that either
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br Regulation of Glu transporters The pivotal role
2021-09-13
Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino m-3M3FBS synthesis calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include t
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It is notable that pharmacological or genetic inhibition
2021-09-13
It is notable that pharmacological or genetic inhibition of GCGR signaling results in the engagement of a number of compensatory mechanisms that potentially impact glucose control. These include alpha-cell hyperplasia [2], [11], [12], [13] and increased beta-cell proliferation under low insulin cond
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Importantly bioelectric circuits in tissues Fig A have a cap
2021-09-13
(4) Importantly, bioelectric circuits in tissues (Fig. 2A) have a capacity to store long-term patterning information. An example is planarian anterior-posterior patterning: during regeneration, each fragment cut from a worm needs to build a head and tail at their correct ends. This process is regula
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The advent of the genomic era has
2021-09-13
The advent of the genomic era has allowed greater detailed investigation of enzymatic properties and has shown that specific enzyme activity is linked to the substrate utilization profiles of the isoenzymes [30], [31]. Not surprisingly, the functional four β-galactosidases from A. niger F0215 shared
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In Gallus gallus four FGFRs
2021-09-13
In Gallus gallus, four FGFRs (FGFR1-4) have been identified, along with 13 FGFs (FGF1–4, 8–10, 12, 13, 16, 18–20) (Thisse and Thisse, 2005). FGFRs are tyrosine kinase receptors that contain an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. Th
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br Conclusion In conclusion our results demonstrate that inc
2021-09-13
Conclusion In conclusion, our results demonstrate that incubation of both LAD and SCA rat coronary arteries rapidly increases the ETB receptor-mediated contraction as well as upregulation of ETB receptor protein levels. These findings may have important experimental implications in tissue bath ex
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br Experimental procedures br Conflicts of interests br Intr
2021-09-13
Experimental procedures Conflicts of interests Introduction Here we investigate differences in growth properties and short-term morphological changes in response to ET-1 in Chinese hamster ovary (CHO) cells stably and separately expressing ETA or ETB receptors. A stably transfected CHO sys
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We found statistically significant association
2021-09-11
We found statistically significant association between p95-HER2 levels and hormone receptor status, Ki-67 Thyroid Hormone Receptor Antagonist (1-850) mg and metastatic regions (p = 0.004, p95-HER2 expression than node-negative ones. Recently, Duchnowska et al. [26] studied the quantitative expressi
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An important aspect of macrophage biology
2021-09-11
An important aspect of macrophage biology, highly influenced by HO-1 activity, is macrophage polarization. The broadest classification, based on the in vitro stimulation, surface marker expression, and inflammatory cytokines production, describes macrophages as classically activated, proinflammatory
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Finally it is possible that the increase in the
2021-09-11
Finally, it is possible that the increase in the number of EAAT-3-labelled cells in the DG at PD 60, when compared with the control and experimental animals at PD 14, is associated with natural changes in the number of neurons present during the postnatal development of the hippocampus (41, 42) and,
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Although no data exist on Ptc gene expression in
2021-09-11
Although no data exist on Ptc52 gene guanidine hydrochloride in other plant species, the expression pattern presented in this study shows perceptibly low levels of transcript accumulation in tomato seeds and roots, low levels in the stem, flower and green fruit, and high levels in the leaves. This c
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One of the possibilities of HO targeting is
2021-09-11
One of the possibilities of HO-1 targeting is gene therapy. So far, the majority of preclinical studies have focused on recombinant adeno-associated viral (rAAV) vectors as DNA carriers. They not only provide stable, long-term transgene expression in non-dividing jak inhibitor but also have very li
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