• The reporter lines allowed us to

  2018-10-20

  

  The reporter lines allowed us to observe in real time that colonies with greater than 300 ciprofloxacin displayed slightly higher expression levels of the reporter at the colonies’ outermost few cell layers (Fig. 1A, F, fluorescence profiles across colonies shown in Supplementary Fig. 2M). This is i

• br Introduction Currently heart disease

  2018-10-20

  

  Introduction Currently, heart disease is the leading cause of mortality in the industrialized world, partly due to the inability of the heart to regenerate in adults; and also the dietary and life style changes leading to a marked increase in the incidence of type II diabetes (for review, see Arm

• In the present study we examined the above mentioned propert

  2018-10-20

  

  In the present study, we examined the above-mentioned properties of MSC-derived exosomes to limit cell death after myocardial I/R injury in vivo. We show that intact exosomes directly target cardiac auda to reduce infarct size. Furthermore, we demonstrate that, in line with our in vitro data, exoso

• In our prior studies we

  2018-10-20

  

  In our prior studies, we showed that K-RasG12D promotes proliferation in the intestinal epithelium by activating MEK, but that K-RasG12D promotes proliferation of colorectal cancer buy ap4 through a MEK-independent mechanism (Haigis et al., 2008). To determine whether K-RasG12D promotes quiescent s

• br Material and methods br

  2018-10-20

  

  Material and methods Results Quiescent cells can be identified in vivo by virtue of their ability to retain label. Historically, this was achieved by treating animals with nucleotide analogues, for example 5-bromo-2′-deoxyuridine (BrdU) or tritiated thymidine, that are incorporated into DNA du

• In the current study we used only gene expression

  2018-10-20

  

  In the current study, we used only gene expression data for the analysis; however, phosphoproteomics data could also be used to assign weights to the signaling interactome for the inference of niche determinants. An important limitation of the method is that it considers only DERs as the sources of

• silybin The relationships of the proximal fetal lung progeni

  2018-10-20

  

  The relationships of the proximal fetal lung progenitor pool characterized in this study to other epithelial cell types remain to be investigated. In the proximal lung of adult animals, either club silybin expressing SCGB1A1 or basal cells expressing KRT5, ITGA6, and NGFR (and others) acts as multip

• br Results br Discussion Adrenergic

  2018-10-20

  

  Results Discussion α-Adrenergic receptors play a critical role in the regulation of cellular growth pathways, including hypertrophy and proliferation. G protein-coupled α1ARs are the predominant α-adrenergic subtype in the myocardium of most species (Brückner et al., 1985), and catecholamine r

• prolyl hydroxylase Here we set out to evaluate the roles of

  2018-10-20

  

  Here we set out to evaluate the roles of transcriptional regulators associated with EMT in iPSC reprogramming. We were intrigued by data from published reports that EMT factors (including SNAI1) increased during the early stages of reprogramming (Mikkelsen et al., 2008; Samavarchi-Tehrani et al., 20

• daunorubicin To address this need we have developed a functi

  2018-10-20

  

  To address this need, we have developed a functional imaging approach for CSC identification. The stem cell phenotype in embryonic stem daunorubicin (ESCs) is maintained by a central triad of master transcriptional regulators, OCT4, SOX2, and NANOG, which promote stemness by upregulating genes invo

• br Results br Discussion Abnormally elevated levels of BMP

  2018-10-20

  

  Results Discussion Abnormally elevated levels of BMP2 were specifically detected in luminal breast tumors but produced by tumor microenvironment and not by cancer anti fungal themselves as reported in leukemia (Gerber et al., 2013; Laperrousaz et al., 2013). Chronic exposure to BMP2 in the pre

• nicergoline br Experimental Procedures br Acknowledgments br

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Master transcription regulators control the pluripotent gene expression in embryonic stem nicergoline (ESCs) (Avilion et al., 2003; Chambers et al., 2003; Mitsui et al., 2003; Nichols et al., 1998). X chromosome inactivation (XCI) is a cr

• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Articular cartilage covers the ends of bones and provides shock RG7388 and lubrication to diarthrodial joints. Articular cartilage is a highly specialized tissue composed of chondrocytes and a specific extracellular matrix (ECM) that con

• In order to clarify such method dependent

  2018-10-20

  

  In order to clarify such method-dependent reprogramming hallmarks, we applied standard assays to compare polycistronic cassettes (constructed in-house or obtained from public resources) in a drug-inducible piggyBac (PB) transposon reprogramming system. The induced expression of various polycistronic

• br Materials and methods br Results br

  2018-10-20

  

  Materials and methods Results Discussion Several in vivo and in vitro studies indicate that OPCs have substantially different properties according to their chronological age. For example, human fetal OPCs from different gestational stages exhibit differences in the myelination profile (Cui

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