• Introduction The World health organization WHO defines acute

  2019-06-26

  

  Introduction The 2008 World health organization (WHO) defines acute leukemias with ambiguous lineage (ALAL) as those leukemias which show no clear differentiation towards either myeloid or lymphoid lineage. It includes acute undifferentiated leukemias which express no specific markers for both line

• Interpretation AMWHO is a useful forum for students to

  2019-06-26

  

  Interpretation AMWHO is a useful forum for students to improve their knowledge of global health issues, and sharpen their skills in diplomacy, communication, problem solving, and conflict resolution. Emory University (Atlanta, GA, USA) will host the next national AMWHO conference in October, 2016. E

• The Zika virus epidemic is spreading countries

  2019-06-26

  

  The Zika virus epidemic is spreading: 63 countries are now reporting transmission, over 1500 cases of related microcephaly or CNS malformations have been confirmed this year, and knowledge on the disease is advancing slowly. Adding to the tension around Zika, at the epicentre of the outbreak, Brazil

• br Introduction Percutaneous transcatheter device closure

  2019-06-26

  

  Introduction Percutaneous transcatheter device closure of atrial septal defects (ASD) has become an effective alternative therapy to surgical repair in patients with secundum type ASD. Amplatzer ASD or ventricular septal defect (VSD) occluders were used for the closure of ASDs or VSDs, respective

• HBV DNA levels are associated

  2019-06-26

  

  HBV DNA levels are associated with clinically significant pathological events, such as cirrhosis; therefore, changes in the serum levels of HBV DNA could determine a risk for hepatocellular carcinoma. For on-treatment follow-up, HBeAg loss/seroconversion is important during the nucleoside therapy fo

• br Material and methods br Results br

  2019-06-26

  

  Material and methods Results Discussion The present study provides clinical, molecular, and in vitro electro-physiological evidence that a rare SNP (KCNE1-D85N) can act as a genetic modifier in LQTS. In general, SNPs are thought to be non-pathological, but some have been reported to modify

• br Diagnostic criteria Brugada syndrome is definitively diag

  2019-06-26

  

  Diagnostic criteria Brugada syndrome is definitively diagnosed when a type-1 ST-segment elevation is observed in at least 1 right precordial lead (V1 and V2) [23], placed in a standard or a superior position (up to the second intercostal space) (Fig. 1C) [24,25], in the presence or absence of a s

• Letsas et al reported that the prevalence of

  2019-06-26

  

  Letsas et al. reported that the prevalence of Brugada-type ECG was 0.34% in men and 0.04% in women in the Greek population [19]. Despite the similar BS gender differences between the Greeks and the Japanese, many multicenter studies performed in Western countries indicated that the frequency of men

• br Conflict of interest br

  2019-06-26

  

  Conflict of interest Acknowledgment Introduction Several investigators recently showed that the superior vena cava (SVC) was one of the major foci for initiating atrial tachyarrhythmias, such as atrial tachycardia (AT) and atrial fibrillation (AF) [1–4]. Conduction block between the atrium

• Bisphosphonates are a well established

  2019-06-26

  

  Bisphosphonates are a well-established, standard-of care treatment option to reduce the frequency and severity and time of onset of the skeletal related events (SREs) in patients with bone metastases due to either solid tumours or multiple myeloma [21–33]. From many years, BPs have been incorporated

• The ability of tumors to progress to more

  2019-06-26

  

  The ability of tumors to progress to more malignant phenotypes depends on tumor microenvironment. Blood capillaries, made up of endothelial cells, are usually static under physiological conditions but are induced to proliferate by direct exposure to angiogenic factors, for instance, vascular endothe

• br Introduction Atrial fibrillation AF is the most

  2019-06-26

  

  Introduction Atrial fibrillation (AF) is the most clinically prevalent tachyarrhythmia [1,2]. AF is a potential risk factor for stroke, and AF-associated strokes are often severe, resulting in disability or death [3–6]. Anticoagulant therapy with the vitamin K antagonist warfarin reduces the risk

• More recently Brugada et al used flecainide to

  2019-06-26

  

  More recently, Brugada et al. [131]. used flecainide to identify the full extent of low-voltage electrogram activity in the anterior RV and RVOT and targeted this region for RFA. In all 14 BrS patients, RFA eliminated abnormal bipolar electrograms, normalized ST-segment elevation on right precordial

• The IntellaTip Mifi catheter has been shown to delineate

  2019-06-26

  

  The IntellaTip Mifi catheter has been shown to delineate local electograms better in the isthmus than the conventional bipolar electrode during atrial flutter ablation. The signal amplitude in the mini-electrodes has been noted to be higher than that of the conventional bipolar catheter. This has en

• The indications for epicardial mapping are institutionally

  2019-06-25

  

  The indications for epicardial mapping are institutionally variable but typically performed after a failed endocardial approach or if the etiology of cardiomyopathy suggests a high likelihood of epicardial scar (Fig. 9). Studies of patients with NICM that underwent combined epicardial–endocardial ap

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