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br Material and methods br Results br Discussion
2019-06-10

Material and methods Results Discussion ES-SCLC is a disease with poor prognosis. Treatment outcome has not improved significantly during the last decades despite great efforts have been made. Maintenance therapy has been tried in several clinical trials with the aim to prevent the onset of
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In addition to CAF in
2019-06-10

In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of
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In a recent study Nademanee et al reported additional
2019-06-10

In a recent study, Nademanee et al. [76]. reported additional evidence pointing to pathologic changes in the RVOT of patients with BrS that have proved undetectable by echocardiography or MRI. In contrast, imaging techniques in ARVC clearly display morphologic and functional changes (e.g., dilation
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A major challenge to the
2019-06-10

A major challenge to the scale-up of provider-initiated HIV testing and counselling is the time needed to provide detailed counselling when faced with inadequate staffing and other competing health-care priorities. Therefore, the Ugandan Ministry of Health developed a brief HIV counselling protocol
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It s springtime for surgery declared
2019-06-10

“It\'s springtime for surgery!” declared Meena Cherian at the launch of the at the end of April. It certainly seems so. In a few days\' time, WHO Member State representatives will gather at the 68th World Health Assembly to discuss, among other things, the adoption a on surgical care and anaesthesia
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In Helen Nabwera and colleagues describe
2019-06-10

In Helen Nabwera and colleagues describe how child growth in a rural African setting has changed during four decades of public health interventions. The investigators analysed data from an unparalleled resource: longitudinal growth monitoring across three Gambian villages spanning 36 years. The long
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The efficiency of additional strategies
2019-06-10

The efficiency of 2 additional strategies for eliminating the substrate for AF maintenance in addition to PVI has been described. Linear lesions are commonly made at the roof between the contralateral superior PVs (roof line), and at the isthmus between the mitral valve and the left inferior PV (mit
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ALW-II-41-27 br Conflict of interest br Introduction Nasopha
2019-06-10

Conflict of interest Introduction Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that line the surface of the nasopharynx. It is a commonly found tumor of the head and neck region in adults, and its incidence varies widely in different regions. It has been observed
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Fourth social rehabilitation and reintegration
2019-06-06

Fourth, social rehabilitation and reintegration of patients with fistula along with sphingosine 1-phosphate receptor modulator sensitisation (to prevent the occurrence of fistula, as well as to mitigate against stigmatisation of fistula survivors) will be crucial to eliminate obstetric fistula. Many
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The immunohistochemistry showed infiltration of CD
2019-06-06

The immunohistochemistry showed infiltration of CD3+ T cells in dermis and few in the epidermis. The double staining of vitiligo biopsies by CD3+ and CD4+ showed that most of CD3+ cells are also CD4+. Whereas, CD3+/CD8+ are present in leading edge and lesional vitiligo skin and showing a mixture of
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br Cardiac imaging br Head up tilt testing Head
2019-06-06

Cardiac imaging Head-up tilt testing Head-up tilt (HUT) testing is recommended to judge an episode of syncope to be likely caused by VF by excluding neurally mediated syncope (NMS). However, NMS may coexist with Brugada syndrome [42]. We conducted HUT testing in 46 patients with type-1 Brugada
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On the other hand it was also shown
2019-06-06

On the other hand, it was also shown that multi-fraction long-course radiotherapy results in better re-calcification and fewer recurrences of spinal cord Nilotinib manufacturer within the irradiated spinal region [24,25]. In case of recurrence, Nieder et al. [10] reviewed that re-irradiation of the
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While resistance to imatinib is rare in patients treated in
2019-06-06

While resistance to imatinib is rare in patients treated in CML-CP, resistance does eventually develop in the majority of patients treated in the advanced phases. In a high proportion of patients who develop secondary resistance after initial responses, point mutations in the BCR-ABL kinase domain h
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Despite a substantial reduction in global
2019-06-06

Despite a substantial reduction in global maternal deaths due to postpartum haemorrhage between 1990 and 2013 (from 71 295 to 44 190), this condition continues to be the main cause of maternal mortality worldwide. In sub-Saharan Africa and south Asia, many women still deliver at home without a skill
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Both typhus and typhoid most commonly
2019-06-06

Both typhus and typhoid most commonly present as undifferentiated febrile illness, defined as fever with no localising features, but have different modes of transmission. Typhoid is transmitted faecal-orally, and typhus is primarily transmitted through insect or mite bites on the skin. is the main
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