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  • This study is important as it tried to

    2018-10-26

    This study is important as it tried to measure the sleep quality (through consecutive measurements) by simultaneously controlling the intervening variables (suffering from medical disorders, psychological disorders, abusing other substances, using psychotherapeutic medications, lapse and relapse) during study. In fact, most patients with amphetamine dependence disorders suffer from poly substance dependence disorder as well. Hence, separating the effects of each substance on sleep-wake MRS 2578 which was done in the present study is very difficult. Also, the high prevalence of comorbidity of amphetamine dependency with aggression, paranoia, and psychosis [14] often necessitates prescription of tranquilizers for patients, which affect the sleep-wake cycle [50]. So studying a pure group of methamphetamine dependents with no psychiatric comorbidity, which was done in the present study, may provide promising and valuable data for the researchers. Moreover, finding patients who can resist against the craving for stimulants for four weeks and also agree to cooperate with psychological assessments is another obstacle which was overcome in our research.
    Limitations This study has its limitations. Lots of patients participated in this study were male. They were severely affected by methamphetamine which they prefer to be institutionalized to reach abstinence. Moreover, the characteristics of the drug used by patients such as dose and duration of abuse were not addressed. It was due to the unreliable reports of participants with methamphetamine dependency in terms of the precise dose and duration, unreliable purity of the illegal drugs they use, irregular pattern of weekly use (for example times of use could changes from week to week for an individual) and gradual tolerance to amphetamines which could attenuate the physiological effects of the specific amount of the drug in consumers [10] and reduce correlation between the characteristic of methamphetamine induced sleep disorders and the amount of methamphetamine which is used.
    Conflict of interest
    Funding Preparation of this manuscript was supported by Grant from Psychiatry and Behavioural Sciences Research Centre, Mashhad University of Medical Sciences (901085).