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Bamboo the fastest growing multipurpose woody plant
2025-02-15
Bamboo, the fastest growing, multipurpose woody plant with a myriad of industrial and domestic uses is intricately associated with the cultural, social and economic conditions of people in many Asian countries. Its uses are not only limited to being used as a substitute for wood in construction, fur
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Finally terbinafine is generally associated
2025-02-15
Finally, terbinafine is generally associated with a low index of toxicity and few adverse effects. In humans, only mild GI toxicity and hepatobiliary dysfunction are reported. In red-tailed hawks, oral administration of a high dose of terbinafine (120 mg/kg BW) was furthermore demonstrated to induce
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Aconitase clusters are prone to oxidations and are
2025-02-15
Aconitase clusters are prone to oxidations and are among the first to undergo a change in transition state during stages of electrophilic stress rendering them inactive [31]. Aconitase activity in LETO and OLETF did not differ at T0 suggesting that the early onset of insulin resistance may not be at
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br Concluding remarks Enhanced membrane binding upon calcium
2025-02-15
Concluding remarks Enhanced membrane binding upon calcium stimulation in membrane transport suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the putative activ
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Recently two distinct small molecule inhibitors of PHGDH
2025-02-15
Recently, two distinct small-molecule inhibitors of PHGDH were identified using high-throughput screens, both of which inhibit de novo serine biosynthesis and show selective toxicity to cancer Plant-derived triterpene with high SSP flux [50,51]. The inhibitor NCT-503, which has an IC50 of 2.5μM, re
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While the mechanisms by which ALDH regulates cardiac respons
2025-02-15
While the mechanisms by which ALDH2 regulates cardiac responses to pathological stress remain unclear, the capillary rarefaction found in pressure-overloaded ALDH2 Tg hearts provides potential clues. Loss of capillary density and diminished endothelial function occur in pathological hypertrophy [46]
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br Glioblastoma GBM is the highest grade glioma Grade
2025-02-15
Glioblastoma GBM is the highest-grade glioma (Grade IV) according to WHO classification and belongs to the most malignant form of desogestrel synthesis tumor. It is an incurable disease despite the use of aggressive treatments that include surgery and radiotherapy, usually in combination with ch
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In addition to plasma membrane sites OCT
2025-02-15
In addition to plasma membrane sites, OCT3 was also observed associated with endomembranes, including mitochondrial membranes, with particularly strong expression in the outer nuclear membranes of both neurons and astrocytes (Gasser et al., 2017), indicating that, in addition to regulating extracell
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br Discussion Here we show
2025-02-15
Discussion Here, we show opposing effects of iontophoretically administered phenylephrine,aselective α1-AR agonist, on firing of putatively DAergic and non-DAergic neurons recorded in vivo in the VTA of urethane anaesthetized rats. Phenylephrine application caused a relatively weak decrease in f
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A highly attenuated B pertussis
2025-02-15
A highly attenuated B. pertussis strain, named BPZE1, has recently been described [10]. It produces enzymatically inactive pertussis toxin (PT), no dermonecrotic toxin and only trace amounts of tracheal cytotoxin. Markedly reduced lung pathology was observed in mice intranasally (i.n.) infected with
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br Concluding remarks ROP is
2025-02-15
Concluding remarks ROP is a major cause of childhood blindness in the world. Current pharmacological therapy focus on anti-VEGF strategy, but this strategy is associated with the unintended effects on delayed eye growth and retinal vasculature development of preterm infants. Preclinical studies u
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br Results and discussion The classical radiochemical
2025-02-15
Results and discussion The classical radiochemical adenosine kinase assays developed to monitor AdK activity utilize [3H]adenosine or [14C]adenosine, respectively. The assays are terminated by spotting the incubation mixture onto diethylaminoethyl (DEAE) anion exchange filter disks or onto a poly
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Cofilin is an additional actin severing
2025-02-15
Cofilin is an additional Boc-MLF severing protein present in sperm cells that undergo phosphorylation/inactivation on serine 3 by Lim kinases (LIMK) and by Tes kinases (TESK) [48]. LIMK can be activated by several pathways, including one through the Rho/ROCK/LIMK cascade [49], [50], [51]. Another wa
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ACE inhibition is often thought to play
2025-02-14
ACE inhibition is often thought to play a central role in the mechanisms of blood pressure reduction in vivo, and most ACE inhibitory (ACEi) peptides were characterized based on in vitro ACE inhibition. A relationship between in vitro ACE inhibition and antihypertensive activity, however, is not app
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br Materials and Methods br Author Contributions br Conflict
2025-02-14
Materials and Methods Author Contributions Conflicts of Interest Acknowledgments This study was funded by the NIH Common Fund (UH2TR000943) through the Office of Strategic Coordination/Office of the NIH Director, an NCI/NIH grant (1R21CA199050), the MD Anderson Cancer Center support gran