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Prednisone br The Farnesoid X receptor FXR identification an
2021-09-26
The Farnesoid X receptor (FXR): identification and ligands The Farnesoid X receptor (FXR) belongs to a family of proteins called Nuclear Receptors (NRs). NRs are a class of ligand-activated transcription factors, which transactivate networks of target genes, thereby mediating a wide range of phys
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br Sources of funding This work
2021-09-26
Sources of funding This work was supported by grants from the Canadian Institutes of Health Research (CIHR) (No. MOP-111096) and from the Heart and Stroke Foundation of Canada awarded to Dr. Danielle Jacques. Disclosures Acknowledgments Introduction A large number of epidemiological, hu
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LB42708 Single cell reverse transcriptase PCR on A mellifera
2021-09-26
Single-cell reverse transcriptase-PCR on A. mellifera antennal lobe (AL) cells showed the expression of RDL as well as another GABA receptor like subunit, LCCH3 (Dupuis et al., 2010). Based on whole cell patch-clamp electrophysiology it was concluded that the predominant GABA receptors in AL cells a
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Subsequently BAs are secreted in the portal
2021-09-26
Subsequently, BAs are secreted in the portal vein by the heterodimeric organic solute transporter OSTα/β [15]. At this level, BAs are transported back to the liver, where the great majority is reabsorbed by the sodium (Na)-Taurocholate Cotransporter Protein (NTCP) and organic anion transporting poly
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With the nitrogen containing heterocycle components and the
2021-09-26
With the nitrogen-containing heterocycle components and the acidic components in hand, the final products were synthesized according to the procedure as depicted in . Reaction of – with various β-substituted phenylpropionic 77 9 (, and ), followed by deprotection by TFA, smoothly provided the corr
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The cases of the Berlin and London patients also
2021-09-26
The cases of the Berlin and London patients also highlight our limits to defining an HIV cure. No signs of the virus have been found in numerous assays with multiple samples from diverse tissues that Timothy Brown has generously contributed to advance research over the past 12 years. In the case of
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In terms of outcome measures statistically significant diffe
2021-09-26
In terms of outcome measures, statistically significant differences were only observed in need for invasive mechanical ventilation (23% vs 46%, p-value 0.005) and in-hospital mortality (13% vs 37%, p-value 0.002). Both these outcomes were still statistically significant following adjustment for conf
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The H autoreceptors distributed mainly
2021-09-26
The H3 autoreceptors distributed mainly in the CNS act as a negative feedback on histamine synthesis and release from histaminergic neurons. Histamine is involved in many physiological functions such as sleep-wake regulation, circadian and feeding rhythm, thermal regulation, locomotion, learning, co
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Allergic rhinitis characterized by inflammation
2021-09-26
Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to Q-VD(OMe)-OPh in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering allergic
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Though studied less extensively than in cholangiopathies and
2021-09-26
Though studied less extensively than in cholangiopathies and fatty liver diseases, the Hh pathway is active in other forms of human liver disease, such as Schistosomiasis[58], [101] and chronic viral hepatitis,[100], [125] as well as in several animal models of liver disease, including drug-induced
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Introduction l Glutamate is a major excitatory neurotransmit
2021-09-24
Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is
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Glucose uptake a critical metabolic control point in glycoly
2021-09-24
Glucose uptake, a critical metabolic control point in glycolysis, is mediated by the GLUT (SLC2) family of integral membrane transporters (Mueckler and Thorens, 2013). GLUT1 (SLC2A1), one of the most well-studied members of the SLC2 family, exhibits a wide tissue distribution; cell surface expressio
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In order to elucidate the reasons of
2021-09-24
In order to elucidate the reasons of high efficacy of , we evaluated the BOC group itself and the linkage between the BOC group and the benzene ring of A-part. Urea moiety (), the replacement of an oxygen hoechst 33342 of the BOC group to a nitrogen atom, decreased the activity (EC = 0.12 μM), while
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br Calcium permeability pathway It
2021-09-24
Calcium permeability pathway It has been demonstrated that physiological shear stress in the circulation causes a reversible increase in Ca2+ permeability [29], [30], [31], [32], [33] and electrophysiological evidence has been recently reported for transient activation of the Ca2+-sensitive K+ ch
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CBR-5884 Introduction Histamine Imidazolyl ethylamine is an
2021-09-24
Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric CBR-5884 secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine exerts i
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