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Ageing is associated with increased reactive oxygen species
2021-06-10
Ageing is associated with increased reactive oxygen species (ROS) production, oxidative stress and oxidative damage [43,44]. Overproduction of ROS can impair endothelial function by suppressing NO synthesis and scavenging NO thereby decreasing its overall bioavailability. Moreover, sustained oxidati
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br Significance Our understanding of the ubiquitin biology h
2021-06-09
Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio
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Although high concentrations of SCR G and
2021-06-09
Although high concentrations of SCR7-G and SCR7-R inhibited LigIV as reported [11], the SCR7 derivatives were more effective inhibitors of LigIIIα and, in particular, LigI. Although it is possible that differences in the DNA substrate underlie this discrepancy, it appears more likely that this refle
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An important strength of our
2021-06-09
An important strength of our study is the use of an elastic net regression model to select the variable and construct the model, which performed ideally in terms of both predictive accuracy and sparsity for the high-dimensional datasets [16]. As a result, the apparent predictive effect of multiple c
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The IL family consists of nine related molecules IL
2021-06-09
The IL-10 family consists of nine related molecules: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28α, IL-28β, and IL-29 [34]. These molecules have a somewhat conserved primary structure and contain a core of hydrophobic pyruvate dehydrogenase kinase inhibitor and two pairs of disulfide bonds in th
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ICV injection of UCN or UCN performed in
2021-06-09
ICV injection of UCN2 or UCN 3 performed in the morning of the 8th day (12h after the last IP administration) seems to increase further the time spent in the open arms of mice exposed to saline or nicotine treatment. Interestingly, in mice exposed to saline treatment ICV injection of UCN 2 or UCN 3
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Social interaction is known to be the main source
2021-06-09
Social interaction is known to be the main source of stress in human beings (Dickerson and Kemeny, 2004, Tamashiro et al., 2005). An animal model of social stress should closely mimic real-life situations in human life (Neisewander et al., 2012); in this context, social defeat in an agonistic encoun
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One strategy which is different from
2021-06-09
One strategy which is different from the above is to isolate a similar enzyme to the one under study which will not be recognized by the antibody of the original protein. This approach will lead to prolonging an enzyme’s activity. For example, a novel variant of Carboxypeptidase G2 (CPG2), which has
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Mild cognitive impairment MCI is a clinical transitional
2021-06-09
Mild cognitive impairment (MCI) is a clinical transitional stage between normal aging and Alzheimer disease (AD) [1]. Approximate 15–30% MCI patients convert to AD annually. Although many efforts have been taken to prevent the conversion from MCI to AD [2], [3], there are few biomarkers to predict t
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The different diagnostic outcomes of the
2021-06-09
The different diagnostic outcomes of the two assays are also dependent on the used stimuli. The QuantiFERON-CMV assay targets CD8 + T Pefloxacin by using peptides whereas the T-Track-CMV targets CD4+ and CD8 + T cells by stimulation with two viral proteins [18]. In our study, a specificity of 100%
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The work described by Dong Groves and co workers tested
2021-06-09
The work described by Dong, Groves, and co-workers (11) tested the hypothesis that neural stem cell development is sensitive to the clustering and mechanical state of the EphB4:ephrin-B2 receptor-ligand complex. They show that the quality of ephrin-B2-ligand signaling depends on its biophysical stat
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OR-486 There are five phosphorylated serines in casein Howev
2021-06-09
There are five phosphorylated serines in β-casein. However, only phosphorylated Ser35 was identified in the samples hydrolysed with GE at 37 and 50 °C, i.e., f32-42 and f32-44 of β-casein. The identification indicates that phosphorylated peptides were less detectable from the non-phosphorylated pept
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br Methods br Results br Discussion Skin
2021-06-08
Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific palmitoylethanolamide reviews organs (Donadio et al., 2005, Donadio et al., 201
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Homologous recombination HR has important
2021-06-08
Homologous recombination (HR) has important roles in the repair of stalled or collapsed DNA replication forks, as well as of DNA double-strand breaks. Among the factors required for HR in human ubiquitin are RAD51, BRCA1, and BRCA2 (Davies et al., 2001, Sung and Klein, 2006, Xia et al., 2001). BRCA
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Db model cells showed various aberrant phenotypes that
2021-06-08
Db model cells showed various aberrant phenotypes that seemed to reflect the pathological abnormalities found under diabetic conditions. First, in Db model cells after insulin stimulation, we found the inhibition of the transcriptional repression of the gluconeogenic genes, PCK1 and G6PC, and aberra
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