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br Materials and methods br Results br Discussion In this
2020-06-19
Materials and methods Results Discussion In this study, we first showed that fluxametamide, a novel isoxazoline insecticide, inhibits agonist responses in two types of LGCCs, the M. domestica GABACl and GluCl, with higher potency in the former channel versus the latter one (Fig. 3). In addi
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br Method Detailed study protocol was reported previously Th
2020-06-19
Method Detailed study protocol was reported previously. The ULTIMATE- HFrEF trial was approved by the Institutional Review Board of our hospital, and the study drug, udenafil, was approved as Investigational New Drug for treatment in patients with chronic HFrEF by Ministry of Food and Drug Safety
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Other enzymes outside of the
2020-06-19
Other A 804598 outside of the circadian clock also have effects on CR. Lithium, a drug used to treat bipolar disorder, has been shown to lengthen τ in a variety of systems [17]. While the molecular mechanism whereby lithium exerts its therapeutic effect is unclear, it is known to be an inhibitor of
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br Materials and methods br Results br Discussion Adiponecti
2020-06-19
Materials and methods Results Discussion Adiponectin is one of the most studied adipocytokines. Its release from adipocytes is down-regulated in obesity and other adverse metabolic conditions leading to decreased serum concentrations (Turer and Scherer, 2012). Several factors and conditions
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In general terms PLA s
2020-06-19
In general terms, PLA2s participate in the Lands cycle of phospholipid fatty Lapatinib recycling [1,15,25], whereby the fatty acid composition at the sn-2 position of phospholipids is tightly controlled by a balance between hydrolytic reactions mediated by PLA2s versus activation of the free fatty
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The inhibition of mRFP Ub E formation by ginsenosides
2020-06-18
The inhibition of mRFP-Ub–E1 formation by ginsenosides Re was not in time-dependent in vitro (Fig. 4B). Fifty micrometres ginsenoside Rg1 decreased E1 activity to 0.24- to 0.36-fold over 30min. This finding suggests that ginsenoside Rg1 may irreversibly inhibit mRFP-Ub–E1 formation or a tight-bindin
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lb100 synthesis We then explored the potential roles of vigi
2020-06-18
We then explored the potential roles of vigilin, along with other proteins which have affinity for the 69 nt CSF-1R element, in breast cancer cells. The sequestration of these proteins by excess 69 nt pyrimidine-rich element increases CSF-1R levels (Figures 2 and 4), and as a result, increases the d
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Because of the complexity of DNA damage and
2020-06-17
Because of the complexity of DNA damage and its repair, several pathways are candidates in HN2-induced DPC repair. Considering the 23kDa molecular weight of MGMT, NER may be ineffective for MGMT-adduct removal. This presumption is supported by that the mRNA level of ERCC1, a core gene in NER pathway
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In conclusion we have discovered two new derivatives
2020-06-17
In conclusion, we have discovered two new derivatives ( and ) that are potent inhibitors of DHODH. H and C NMR spectroscopic data revealed that these compounds undergo ready isomerisation at room temperature in -DMSO, but the docking studies indicate that there is neither conformation nor configurat
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In our preliminary evaluation of
2020-06-17
In our preliminary evaluation of this series, we were surprised to discover that T7 High Yield Fluorescein RNA was found to bind CSF-1R in a classical DFG-in binding mode (a). Dramatic conformational differences in the juxtamembrane domain and activation loops are apparent when this DFG-in structu
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br Experimental br Results br Discussion In the last two
2020-06-17
Experimental Results Discussion In the last two decades, several studies have shown an important role for progestogens, and in particular ALLO, in the modulation of Schwann cell physiology, regulating several biochemical and functional parameters. The classical PR has been found both in rat
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Our study revealed elevated basal Akt
2020-06-17
Our study revealed elevated basal Akt phosphorylation in diet-induced obesity, the effect of which was reversed by ETAKO. Activation of Akt promotes cardiac hypertrophy via a number of cellular mechanisms including activation of its downstream targets such as mTOR and GSK3β [45, 46]. Short-term acti
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Preliminary studies suggest that dimerization of
2020-06-17
Preliminary studies suggest that dimerization of the AT1 receptor occurred during the biosynthesis in the endoplasmic reticulum before surface expression [27,40], which may explain the presenece of these Tianeptine sodium before the addition of any ligand. Our results showed that the presence of An
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A prominent example of such enzyme is the proteasome
2020-06-17
A prominent example of such enzyme is the proteasome, a highly promising target not only in cancer, but also in inflammatory and autoimmune diseases. Circulating proteasomes and respective anti-proteasome autoantibodies were detected in serum samples from patients with autoimmune diseases such as mu
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br E intracellular localization br Regulation of
2020-06-17
E1 intracellular localization Regulation of E1 by other post-translational modifications Concluding remarks Acknowledgments We apologize to those whose work was not included because of space considerations or whose papers were unintentionally omitted. We thank Dr Peter Bullock (Tufts Uni
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