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br Materials and methods br Results br Discussion We
2018-11-08
Materials and methods Results Discussion We have demonstrated the efficient generation of high numbers of bfCNs from hPSCs via an expandable basal forebrain NSC intermediate. This is of particular interest as bfCNs are one of the primary populations affected in AD, and our protocol provides
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br Introduction There are million
2018-11-08
Introduction There are 382million people with diabetes worldwide. All patients with Type I and approximately 25% of patients with Type II diabetes require exogenous insulin to survive (Koro et al., 2004). Unfortunately, insulin injections cannot match the minute-to minute precision that islets pr
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To further examine the influence of microgravity mechanical
2018-11-08
To further examine the influence of microgravity mechanical unloading on differentiation of mesenchymal and hematopoietic lineages, we investigated genes associated with terminal differentiation of these lineages. We found a broad down-regulation of early to mid stage differentiation markers and dow
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During neonatal and post natal development oligodendrocytes
2018-11-08
During neonatal and post-natal development, oligodendrocytes are abundantly produced in three temporally distinct waves (Kessaris et al., 2006), and differentiated oligodendrocytes express specific markers according to the state of development (Zhang, 2001). In the initial stage of differentiation,
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Pediatric MDS is a very rare disease and
2018-11-08
Pediatric MDS is a very rare disease and publications on the role of stroma in the ontogeny and maintenance of pediatric MDS are limited to a case report on aberrant hematopoietic support by MSC derived from an MDS patient with trisomy 8 (Narendran et al., 2004), a study using stroma testes of of 7
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br Methods br Results br Discussion
2018-11-08
Methods Results Discussion Originally, human bone marrow-derived CD34+ adenosine receptor agonist were defined as hematopoietic stem/progenitor-rich cells, while endothelial progenitor cells (EPCs), which play an important role in post-natal angiogenesis/vasculogenesis in ischemic tissues,
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br Materials and methods br
2018-11-08
Materials and methods Verification and authentication Karyotyping was performed at the Center for Applied Human Molecular Genetics, Kennedy Center, Glostrup, Denmark. At least 10 metaphases were analyzed per sample with an approximate resolution of 550 to 600 bands per haploid genome. The resu
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Microarray based global hierarchical clustering clearly sepa
2018-11-08
Microarray-based global hierarchical clustering clearly separated all the directly isolated keratinocyte populations. In the first round of analysis () where we focused on known and well characterized populations the Plet population clearly separated from the rest of the populations, which is probab
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The karyotype of the BIOT LOAD
2018-11-08
The karyotype of the BIOT-4828-LOAD iPSC line was determined with Giemsa-banding, proving normal diploid 46, XX karyotype, without any detectable abnormalities (Fig. 1B). Expression of pluripotency markers was examined by immunocytochemistry staining, using pdgfr against human OCT3/4, E-CADHERIN, a
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br Conclusions The following are the supplementary
2018-11-08
Conclusions The following are the supplementary data relate to this article. Disclosure of potential conflicts of interest Acknowledgments We thank Fondazione Roma for continuous support. We also acknowledge Prof. Mara Riminucci, Prof. Luca Pierelli, Dr. C. Murdoch, Dr. Paola Iudicone and
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pterostilbene Introduction The stem cells extracted from the
2018-11-08
Introduction The stem cells extracted from the inner cell mass of an embryo are pluripotent, i.e. they have unique ability of long-term self-renewal and the potential to develop into all specialized cell types (Evans and Kaufman, 1981; Martin, 1981). However, embryonic stem cells with different ori
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The leading approaches to this are DA
2018-11-08
The leading approaches to this are DA cell transplantation, or stimulating endogenous DA neurogenesis, in either SNc or its efferent target the dorsal striatum. Despite progression of cell transplantation to clinical trials, it is still not widely available due to lack of a standardized and morally
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Safe Ca antagonists are already used clinically
2018-11-08
Safe Ca2+ antagonists are already used clinically, and convincing (albeit limited) evidence supports their use in LQTS diseases that resist conventional pharmacotherapy (Iseri and French, 1984; Jackman et al., 1990; Komiya et al., 2004). However, physicians appear hesitant to prescribe Ca2+ antagoni
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In addition to apoptosis we investigated the
2018-11-08
In addition to apoptosis, we investigated the occurrence of DNA lesions in response to genotoxic insults. Using LORD-Q analyses, a novel sensitive technique to quantify DNA lesions (Lehle et al., 2014), we found that, despite their elevated apoptosis sensitivity, iPSCs accumulated significantly less
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br Introduction In mammals cells from the blastocyst stage c
2018-11-08
Introduction In mammals, cells from the abacavir stage can be used to form embryonic stem (ES) cell lines that can self-renew in culture while maintaining the ability to differentiate into cells of the three germ layers (Reubinoff et al., 2000). Directed in vitro differentiation protocols general
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